2024
Bessler R and Sznitman J. The potential of leveraging electrostatics for improved inhaled drug delivery to the lungs. Frontiers in Medical Engineering 1: 1298251, 2024.
2023
Bessler R, Bhardwaj S, Malka D, Fishler R, and Sznitman J. Exploring the role of electrostatic deposition on inhaled aerosols in alveolated microchannels. Scientifc Reports 13: 23069, 2023.
Oakes JM, Amirav I, and Sznitman J. Pediatric inhalation therapy and the aerodynamic rationale for age-based aerosol sizes. Expert Opinion in Drug Delivery 20: 037-1040, 2023. (just an update of vol, pages)
Nof E, Bhardwaj S, Bessler R, Koullapis P, Kassinos SC, and Sznitman J. In vitro – in silico correlation of three-dimensional turbulent flows in an idealized mouth-throat model. PLoS Computational Biology 19: e1010537, 2023.
Allon R, Bhardwaj S, Sznitman J, Shoffel-Havakuk H, Pinhas S, Zloczower E, Shapira-Galitz Y, Lahav Y. A Novel Trans-Tracheostomal Retrograde Inhalation Technique Increases Subglottic Drug Deposition Compared to Traditional Trans-Oral Inhalation. Pharmaceutics. 2023; 15(3):903.
Zheng P, Apsley D, Zhong S, Sznitman J and Smits AJ. Image systems for regularized Stokeslets at walls and free surfaces. European Journal of Mechanics – B/Fluids 97: 112-127, 2023.
Fishler R, Ostrovski Y, Frankel A, Dorfman S, Vaknin M, Waisman D, Korin N and Sznitman J. Exploring pulmonary distribution of intratracheally instilled liquid foams in excised porcine lungs. European Journal of Pharmaceutical Sciences 181: 106359, 2023.
2022
Sznitman J. Revisiting airflow and aerosol transport phenomena in the deep lungs with microfluidics. Chemical Reviews, 122: 7184-7204, 2022.
Nof E, Zidan H, Artzy-Schnirman A, Mouhaded O, Beckerman M, Bhardwaj S, Elias-Kirma S, Gur D, Beth-Din A, Levenberg S, Korin N, Ordentlich A, and Sznitman J. Human multi-compartment airways-on-chip platform for emulating respiratory airborne transmission: from nose to pulmonary acini. Frontiers in Physiology 13: 853317, 2022.
Bhardwaj S, Koullapis P, Kassinos SC, and Sznitman J. Fate of inhaled aerosols under the influence of glottal motion in a realistic in silico human tracheobronchial tree model. European Journal of Pharmaceutical Sciences 173: 106172, 2022.
Belenkovich M, Sznitman J, and Korin N. Microparticle entrapment dynamics in microfluidic pulmonary capillary network. Journal of Biomechanics, 137: 111082, 2022.
Fishler R, Ostrovski Y, Vaknin M, and Sznitman J. Shear thinning effect on liquid foam distribution in heterogeneously constricted in vitro airway models. Journal of Biomechanics 140: 111131, 2022.
Cohen N, Vagima Y, Mouhadeb O, Toister E, Guttman H, Lazar S, Jayson A, Artzy-Schnirman A, Sznitman J, Ordentlich A, Yitzhaki S, Seliktar D, Mamroud E, and Epstein E. PEG-Fibrinogen hydrogel microsphere as a scaffold for therapeutic delivery of immune cells. Frontiers in Bioengineering & Biotechnology 10: 905557, 2022.
2021
Nof, E., Artzy-Schnirman, A., Bhardwaj, S., Sabatan, H., Waisman, D., Hochwald, O., Gruber, M., Borenstein-Levin, L., and Sznitman, J. Ventilation-induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with prophylactic anti-inflammatory therapeutics. Bioengineering & Translational Medicine, e10271, 2021
Carius P, Dubois A, Ajdaridad M, Artzy-Schnirman A, Sznitman J, Schneider-Daum N, and Lehr CM. PerfupPul – a versatile perfusable platform to assess permeability and barrier function of air exposed pulmonary epithelia. Frontiers in Bioengineering & Biotechnology, in press, 2021
Lehr CM, Yeo L, and Sznitman J. Innovative in vitro models for pulmonary physiology and drug delivery in health and disease. Frontiers in Bioengineering & Biotechnology, in press, 2021
Wang CC, Prather KA, Sznitman J, Jimenez JL, Lakdawala SS, Tufekci Z and Marr LC. Airborne transmission of respiratory viruses. Science, 373:eabd9149, 2021
Artzy-Schnirman A, Raviv SA, Flikshtain OD, Shklover J, Korin N, Gross A, Mizrahi B, Schroeder A and Sznitman J. Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics. Advanced Drug Delivery Reviews, 176: 113901, 2021
Elias‐Kirma S, Artzy-Schnirman A, Sabatan H, Dabush C, Waisman D, and Sznitman J.Towards homogenization of liquid plug distribution in reconstructed 3D upper airways of the preterm infant. Journal of Biomechanics, 122:110458, 2021
Siman-Tov R, Zelikson N, Caspi M, Levi Y, Perry C, Khair H, Stauber H, Sznitman J, and Rosin-Arbesfeld R. Circulating Wnt ligands activate the Wnt signaling pathway in mature erythrocytes. Arteriosclerosis Thrombosis and Vascular Biology, 41, 2021, https://doi.org/10.1161/ATVBAHA.120.315413
Koullapis P, Stylianou F, Lin C-L, Kassinos SC and Sznitman J. In silico methods to model dose deposition. Kassinos SC, Baeckman P, Conway J and Hickey AJ (ed.), Inhaled Medicines, Academic Press, 2021.
Ostrovski Y, Dorfman S, Poh W, Loo SCJ, and Sznitman J. Focused targeting of inhaled magnetic aerosols in reconstructed in vitro airway models. Journal of Biomechanics, 118:110279, 2021
Goldenberg H, Gandara BP, Perez J, Bramante A, Foronjy R, Dabo AJ, Eden E, Sznitman J, and Geraghty P. Nicotine in e-cigarettes dysregulates pulmonary inflammation and MMP-12 expression without effecting respiratory syncytial virus virulence. Journal of Respiration, 1:60-73, 2021
2020
Fishler R, Ostrovski Y, Frenkel A, Dorfman S, Brod V, Haas T, Waisman D and Sznitman J. Liquid foam therapy (LiFT) for homogenous distribution of exogenous pulmonary surfactant in ARDS. 2020, https://doi.org/10.1101/2020.11.30.403337
Christou S, Chatziathanasiou T, Angeli S, Koullapis P, Stylianou F, Sznitman J, Guo HH and Kassinos SC. Anatomical variability in the upper tracheobronchial tree: sex-based differences and implications for personalized inhalation therapies. Journal of Applied Physiology, 2020, https://doi.org/10.1152/japplphysiol.00144.2020 (In press)
Heller-Algazi M, Nof E, Das P, Bhardwaj S, Kassinos S and Sznitman J. In silico optimization of targeted aerosol delivery in upper airways via Inhaled Volume Tracking. Clinical Biomechanics, 80: 105138, 2020.
Artzy-Schnirman A, Lehr CM and Sznitman J. Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips. Expert Opinion on Drug Delivery, 17: 621-625, 2020.
Shachar-Berman L, Bhardwaj S, Ostrovski Y, Das P, Koullapis P, Kassinos S and Sznitman J. In Silico Optimization of Fiber-Shaped Aerosols in Inhalation Therapy for Augmented Targeting and Deposition across the Respiratory Tract. Pharmaceutics, 12: 230, 2020.
Koullapis P, Stylianou FS, Sznitman J, Olsson B and Kassinos SC. Towards whole-lung simulations of aerosol deposition: A model of the deep lung. Journal of Aerosol Science, 144: 105541, 2020.
Ehrmann S, Schmid O, Darquenne C, Rothen-Rutishauser B, Sznitman J, Yang L, Barosova H, Vecellio L, Mitchell J and Heuze-Vourc’h N. Innovative preclinical models for pulmonary drug delivery research. Expert Opinion on Drug Delivery, in press, 17: 463-478, 2020.
Elias‐Kirma S, Artzy-Schnirman A, Das P, Heller-Algazi M, Korin N, and Sznitman J. In situ-like aerosol inhalation exposure for cytotoxicity assessment using airway-on-chip platforms. Frontiers in Bioengineering and Biotechnology, 8: 91, 2020.
Nof E, Heller-Algazi M, Coletti F, Waisman D, Sznitman J. Ventilation-induced jet suggests biotrauma in reconstructed airways of the intubated neonate. Journal of the Royal Society Interface 17: 20190516, 2020.
2019
Zuckerman H, Khoury M, Shammay Y, Sznitman J, Lotan N, and Korin N. Targeting functionalized nanoparticles to activated endothelial cells under high wall shear stress. Bioengineering & Translational Medicine e10151, 2019.
Inthavong K, Das P, Singh N and Sznitman J. In silico approaches to respiratory nasal flows: A review. Journal of Biomechanics 97: 109434, 2019.
Koullapis P, Ollson B, Kassinos SC and Sznitman J. Multiscale in silico Lung Modeling Strategies for Aerosol Inhalation Therapy and Drug Delivery. Current Opinion in Biomedical Engineering, 11: 130-136, 2019.
Poh W, Rahman ABN, Ostrovski Y, Sznitman J, Perthe K and Loo J. Active Pulmonary Targeting against Tuberculosis (TB) via Triple–Encapsulation of Q203, Bedaquiline and Superparamagnetic Iron Oxides (SPIOs) in Nanoparticle Aggregates, Drug Delivery 26: 1039-1048, 2019.
Artzy-Schnirman A, Hobi N, Schneider-Daum N, Guenat OT, Lehr CM and Sznitman J, Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline, European Journal of Pharmaceutics and Biopharmaceutics 144: 11-17, 2019.
Artzy-Schnirman A, Zidan H, Elias-Kirma S, Ben-Porat L, Tenenbaum-Katan J, Carius P, Fishler R, Schneider-Daum N, Lehr CM and Sznitman J, Capturing the onset of Bacterial Pulmonary Infection in Acini-on-Chips, Advanced Biosystems 3: 1900026, 2019.
Shachar-Berman L, OstrovskiY , Koshiyama K, Wada S, Kassinos S and Sznitman J, Targeting inhaled fibers to the pulmonary acinus: Opportunities for augmented delivery from in silico simulations, Eur. J. Pharm. Sci. 137: 105003, 2019.
Sznitman J. Preface: Clinical relevance of respiratory mechanics and flows. Clinical Biomechanics 66:1, 2019.
Bauer K, Nof E, and Sznitman J. Revisiting high-frequency oscillatory ventilation in vitro and in silico in neonatal conductive airways. Clinical Biomechanics 66: 5-59, 2019.
Ostrovski Y, Dorfman S, Mezhericher M, Kassinos SC, and Sznitman J. Targeted drug delivery to upper airways using a pulsed aerosol bolus and inhaled volume tracking method. Flow, Turbulence and Combustion 102: 73-87, 2019.
2018
Das P, Nof E, Amirav I, Kassinos SC, and Sznitman J. Targeting inhaled aerosol delivery to upper airways in children: insight from computational fluid dynamics. PLoS One 13: e0207711, 2018.
Tenenbaum-Katan J, Artzy-Schnirman A, Fishler R, Korin N, and Sznitman J. Biomimetics of the pulmonary environment in vitro: A microfluidics perspective. Biomicrofluidics 12: 042208, 2018.
Korin N and Sznitman J. Preface to special topic: bio-transport processes and drug delivery in physiological micro-devices. Biomicrofluidics 12: 042101, 2018.
Fishler R, Verhoeven F, de Kruijf W, and Sznitman J. Particle sizing of pharmaceutical aerosols via direct imaging of particle settling velocities. European Journal of Pharmaceutical Sciences, 113: 152-158, 2018.
Shachar-Berman L, Ostrovski Y, Kassinos SC, and Sznitman J. Transport of ellipsoid fibers in oscillatory shear flows: implications for aerosol deposition in deep airways. European Journal of Pharmaceutical Sciences, 113: 145-151, 2018.
Koullapis PG, Hofemeier P, Sznitman J, and Kassinos SC. An efficient computational fluid-particle dynamics method to predict deposition in a simplified approximation of the deep lung. European Journal of Pharmaceutical Sciences, 113: 132-144. 2018.
Hofemeier P, Koshiyama K, Wada S, and Sznitman J. One (sub-)acinus for all: Fate of inhaled aerosols in heterogeneous pulmonary acinar structures. European Journal of Pharmaceutical Sciences 113: 53-63, 2018.
2017
Stauber H, Waisman D, Korin N, and Sznitman J. Red blood cell (RBC) suspensions in confined microflows: Pressure-flow relationship. Medical Engineering & Physics 48: 49-54, 2017.
Fishler R and Sznitman J. Novel aerodynamic sizing method using image-based analysis of settling velocities. Inhalation 11: 21-25, 2017.
Fishler R and Sznitman J. Acini-on-Chip: Novel In Vitro Assessment of Particle Dynamics and Deposition in the Deep Lungs. RDD Europe 2017. Volume 1: 119-128, 2017.
Fishler R and Sznitman J. Computer Vision-based Aerodynamic Particle Sizing: A Rapid Method for Real-time Characterization of Inhaled Aerosols. RDD Europe 2017. Volume 2: 305-308, 2017.
Stauber H, Waisman D, Korin N, and Sznitman J. Red blood cell dynamics in microfluidic networks of pulmonary alveolar capillaries, Biomicrofluidics 11: 014103, 2017
Fishler R, Ostrovski Y, Lu C-Y, and Sznitman J. Streamline crossing: an essential mechanism for aerosol dispersion in the pulmonary acinus, Journal of Biomechanics, 50: 222-227, 2017 .
2016
Stylianou FS, Sznitman J, and Kassinos SC. Direct numerical simulation of particle laden flow in a human airway bifurcation model, International Journal of Heat and Fluid Flow 61: 677-710, 2016
Hofemeier P and Sznitman J. The role of anisotropic expansion for pulmonary acinar deposition. Journal of Biomechanics 49: 3543-3548, 2016.
Ostrovski Y, Hofemeier P, and Sznitman J. Augmenting Regional and Targeted Delivery in the Pulmonary Acinus using Magnetic Particles, International Journal of Nanomedicine 11: 3385-3395, 2016.
Sznitman J and Steinman DA, Relevance and challenges of computational fluid dynamics in the biomedical sciences, Journal of Biomechanics 49: 2101, 2016.
Tenenbaum-Katan J, Hofemeier P and Sznitman J. Computational Models of Inhalation Therapy in early Childhood: Therapeutic Aerosols in the Developing Acinus, Journal of Aerosol Medicine and Pulmonary Drug Delivery 29: 288-298, 2016.
Oakes J M*, Hofemeier P*, Vignon-Clementel I E, and Sznitman J. Aerosols in Healthy and Emphysematous In Silico Pulmonary Acinar Rat Models, Journal of Biomechanics 49: 2213-2220, 2016. *Authors contributed equally
Hofemeier P, Shachar-Berman L, Tenenbaum-Katan, Filoche M and Sznitman J. Unsteady Diffusional Screening in 3D Pulmonary Acinar Structures: from Infancy to Adulthood, Journal of Biomechanics 49: 2193-2200, 2016.
Fishler, R, and Sznitman J. A Microfluidic Model of Biomimetically-Breathing Pulmonary Acinar Airways, Journal of Visualized Experiments 111: e53588, 2016.
2015
Stauber H, Fishler R, Hofemeier P, Waisman D and Sznitman J. Particle Dispersion in Morphologically-Inspired Computational Models of Alveolar Capillary Networks, International Journal of Experimental and Computational Biomechanics, Vol. 3, No. 4, 2015 pp. 300-318, 2015.
Fishler R, Hofemeier P, Etzion Y, Dubowski Y and Sznitman J. Particle dynamics and deposition in true-scale pulmonary acinar models, Scientific Reports, 12071, 2015.
Hofemeier P and Sznitman J. Revisiting pulmonary acinar particle transport: convection, sedimentation, diffusion and their interplay, Journal of Applied Physiology 118: 11, 1375-1385, 2015.
Marom A, Kumar Mahto S, Shor E, Tenenbaum-Katan J, Sznitman J, and Shoham S. Microfluidic Chip for Site-Specific Neuropharmacological Treatment and Activity Probing of 3D Neuronal “Optonet” Cultures, Advanced Healthcare Materials 4: 10, 1478–1483, 2015.
Koren L, Sznitman R, Carls C, Krajacic P, Arratia PE, Brown AEX, and Sznitman J. Model-independent phenotyping of C. elegans locomotion using Scale-Invariant Feature Transform, PLoS One: 10.3, e0122326 (2015).
Tenenbaum-Katan J, Fishler R, Rothen-Rutishauser B, and Sznitman J. Biomimetics of fetal alveolar flow phenomena using microfluidics. Biomicrofluidics: 9, 014120 , 2015.
Sznitman J and Arratia PE, Locomotion through Complex Fluids: an Experimental View, S.E. Spagnolie (ed.), Complex Fluids in Biological Systems, Biological and Medical Physics, Biomedical Engineering, Springer Science+Business Media New York 2015.
Tenenbaum-Katan J, Fishler R, Rothen-Rutishauser B, and Sznitman J. Microfluidic in vitro platforms of pulmonary alveolar physiology. in IFMBE Proceedings 6th European Conference of the International Federation for Medical and Biological Engineering, Volume 45, 2015, pp 777-780, 2015.
Mahto SK, Charwat V, Ertl B, Rothen-Rutishauser B, and Sznitman J. Microfluidic platforms for advanced risk and cellular assessments of nanomaterials, Nanotoxicology 9: 381-395, 2015.
2014
Greenblum A, Sznitman R, Fua P, Arratia PE, Oren M, Podbilewicz B, and Sznitman J. Dendritic tree extraction from noisy Maximum Intensity Projection images in C. elegans, BMC Biomed Eng Online 13(1): 74, 2014.
Hofemeier P, and Sznitman J. Role of alveolar topology on acinar flows and convective mixing, Journal of Biomechanical Engineering: 136(6), 061007, 2014.
Mahto SK, Tenenbaum-Katan J, Greenblum A, Rothen-Rutishauser B, and Sznitman J. Microfluidic shear stress-regulated surfactant secretion in alveolar epithelial type II cells in vitro, American Journal of Physiology Lung Cell Mol. Physiol. 306(7): L672-L683, 2014.
Hofemeier P, Fishler R, and Sznitman J. The role of respiratory flow asynchrony on convective mixing in the pulmonary acinus, Fluid Dynamics Research 46: 041407, 2014.
Greenblum A, Sznitman R, Fua P, Arratia PE, and Sznitman J. Caenorhabditis elegans segmentation using texture-based models for motility phenotyping, IEEE Transactions in Biomedical Engineering 61(6): 2278 – 2289, 2014.
2013
Fishler R, Mulligan MK, and Sznitman J. Acinus-on-a-chip: a microfluidic platform for respiratory acinar flows, Journal of Biomechanics 46: 2817 – 2823, 2013.
Berman R, Oded K, Sznitman J, and Leshansky A. Undulatory locomotion of finite filaments, New Journal of Physics 15: 075022, 2013.
Fishler R, Mulligan MK, and Sznitman J. Mapping low-Reynolds-number microcavity flows using microfluidic screening devices, Microfluidics and Nanofluidids 15: 491 – 500, 2013.
Sznitman J, Stone HA, Smits AJ, and Grotberg JB. Teaching the falling ball problem with dimensional analysis, European Journal of Physics Education 4(2):
32 – 42, 2013.
Sznitman J. Respiratory microflows in the pulmonary acinus, Journal of Biomechanics 46: 284 – 298, 2013.
2012
Ghosh R, and Sznitman J. Visualization of nematode C. elegans swimming in a drop, Journal of Visualization 15: 277–279, 2012.
Mahto SK, Tenenbaum-Katan J, and Sznitman J. Respiratory physiology on a chip, Scientifica ID 364054 (12 pages), 2012.
Sznitman J, Guglielmini L, Clifton D, Scobee D, Stone HA, and Smits AJ. Experimental characterization of 3D corners flows at low Reynolds numbers, Journal of Fluid Mechanics 707: 35 – 52, 2012.
Shen X, Sznitman J, Krajacic P, Lamitina P, and Arratia PE. Undulatory locomotion of C. elegans on wet surfaces, Biophysical Journal 102: 2772-2781, 2012.
Spycher B, Wildhaber JH, Frey U, and Sznitman J. Mathematical behavior of MEFV curves in childhood asthma and the role of curvature in quantifying flow obstruction, ISRN Pulmonology ID 305176 (13 pages), 2012.
2010
Sznitman R, Gupta M, Hager GD, Arratia PE, and Sznitman J. Multi environment model estimation for motility analysis of Caenorhabditis Elegans, PLOS One 5(7): e11631, 2010.
Sznitman J, Shen X, Sznitman R, and Arratia PE. Flow behavior and force measurements of undulatory swimmers at low Reynolds number, Physics of Fluids 22: 121901, 2010.
Juarez G, Lu K, Sznitman J, and Arratia PE. Motility of small nematodes in wet granular media, Europhysics Letters 92: 44002, 2010.
Sznitman J, Shen X, Purohit PK, and Arratia PE. The effects of fluid viscosity on the kinematics and material properties of C. elegans swimming at low Reynolds number, Experimental Mechanics 50: 1303-1311, 2010.
Sznitman J, Sutter R, Altorfer D, Stampanoni M, R ̈sgen T, and Schittny JC. Visualization of respiratory flows in reconstructed 3D terminal alveolar airspaces using X-ray tomographic microscopy, Journal of Visualization 13: 337-345, 2010.
Sznitman J, Purohit PK, Krajacic P, Lamitina T, and Arratia PE. Material properties of Caenorhabditis elegans swimming at low Reynolds number, Biophysical Journal 98: 617-626, 2010.
Sznitman J, and Roesgen T. PIV investigation of low-Reynolds boundary driven cavity flows in thin liquid shells, Journal of Visualization 13: 49 – 60, 2010.
2009 and earlier
Sznitman J. Convective gas transport in the pulmonary acinus: comparing roles of convective and diffusive lengths, Journal of Biomechanics 42: 789 – 792, 2009.
Sznitman J, Heimsch T, Wildhaber JH, Tsuda A, and Roesgen T. Respiratory flow phenomena and gravitational deposition in a three-dimensional space-filling model of the pulmonary acinar tree, Journal of Biomechanical Engineering 131: 031010, 2009.
Sznitman J, and Roesgen T. Acoustic streaming visualization in elastic spherical cavities, Journal of Visualization 11: 347 – 355, 2008.
Sznitman J, and Roesgen T. Acoustic streaming flows in a cavity: an illustration of small-scale inviscid flow, Physica D 237: 2240 – 2246, 2008.
Sznitman J, and Roesgen T. Formation of negative buoyant vortex rings at an orifice opening, International Journal of Transport Phenomena 10: 37 – 45, 2008.
Sznitman J, and Roesgen T. Low-Reynolds boundary driven cavity flows in a thin liquid shell, PAMM 7: 4100007-4100008, 2007.
Wildhaber JH, Sznitman J, Harpes P, Straub D, Moeller A, Basek P, and Sennhauser FH. Correlation of spirometry and symptom scores in childhood asthma and the usefulness of curvature assessment in expiratory flow-volume curves, Respiratory Care 52: 1744-1752, 2007.
Sznitman J, Heimsch F, Heimsch T, Rusch D, and Roesgen T. Three-dimensional convective alveolar flow induced by rhythmic breathing motion of the pulmonary acinus, Journal of Biomechanical Engineering 129: 658-665, 2007.
Sznitman J, and Roesgen T. Optical density visualization and Abel reconstruction of vortex rings using background-oriented Schlieren, Journal of Visualization 10: 5, 2007.
Sznitman J, and Roesgen T. Whole-field density visualization and Abel recontruction of axisymmetric vortex rings, Journal of Flow Visualization and Image Processing 13: 343-358, 2006.
Bruehwiler PA, Buyan M, Huber R, Bogerd CP, Sznitman J, Graf SF, and Roesgen T. Heat Transfer Variations of Bicycle Helmets, Journal of Sports Science 24: 999-1011, 2006.